Home

JOHN EBERSOLE, M.D.
Professor, Department of Neurology
Director, Adult Epilepsy Service
Co-Director, Comprehensive Epilepsy Center

Background
Dr. Ebersole came to the University of Chicago in January 2000 from Yale University, where he was Professor of Neurology, Director of the Yale - New Haven Hospital EEG Laboratory and Director of the Yale - West Haven VA Epilepsy Center.  Here at the University of Chicago, Dr. Ebersole has assumed the position of Director of the Adult Epilepsy Service and Co-Director of the Comprehensive Epilepsy Program.  He supervises the operation of the new Epilepsy Monitoring Unit in the Bernard Mitchell Hospital.  Dr. Ebersole is an internationally recognized authority on epilepsy and the use of advanced EEG techniques for the diagnosis, classification, and brain localization of epilepsy.  He has served as Treasurer of the American Epilepsy Society, President of the American EEG Society, and Chairman of the American Board of Clinical Neurophysiology.  He is Currently Editor-in-Chief of the Journal of Clinical Neurophysiology. 

Clinical Interests
The diagnosis and treatment of seizure disorders that have been difficult to understand or control with standard antiepileptic medications are the principal interests of Dr. Ebersole.  Although he specializes in the evaluation of patients with uncontrolled seizures for possible surgical therapy, he is equally interested in diagnostic and classification problems and treatment with the most up-to-date medications.  Dr. Ebersole oversees the operation of the Epilepsy Monitoring Unit where the EEG and video of patients can be recorded continuously for several days in order to characterize their seizures and localize the origin within the brain.  Dr. Ebersole sees new patients weekly in clinics at the Center for Advanced Medicine. 

Research Interests
Dr. Ebersole's clinical research program is aimed at developing and validating computer-based techniques of functional imaging and localization using scalp and intracranial EEG.  Over the past past ten years research from his laboratory has established the usefulness of spike and seizure source modeling with both EEG and MEG in order to localize non-invasively epileptogenic foci in epilepsy surgery candidates.  Ongoing projects include studies of dipole and extended source models of epileptic foci, development of realistic head and brain models for source computations, and co-registration of scalp and intracranial EEG onto 3-D MRI reconstructions of the head and brain, respectively.